CHCHD2 connects mitochondrial metabolism to apoptosis
نویسندگان
چکیده
As the powerhouse of cells and gatekeeper for apoptosis, mitochondria control life and death. CHCHD2, a mitochondrial protein previously known to regulate metabolism, has recently been identified as an apoptosis inhibitor. New data suggest a model in which CHCHD2 performs a prosurvival function by acting as both a reactive oxygen species scavenger and BCL-XL activator.
منابع مشابه
Loss of Parkinson's disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c
Mutations in CHCHD2 have been identified in some Parkinson's disease (PD) cases. To understand the physiological and pathological roles of CHCHD2, we manipulated the expression of CHCHD2 in Drosophila and mammalian cells. The loss of CHCHD2 in Drosophila causes abnormal matrix structures and impaired oxygen respiration in mitochondria, leading to oxidative stress, dopaminergic neuron loss and m...
متن کاملThe mitochondrial protein CHCHD2 primes the differentiation potential of human induced pluripotent stem cells to neuroectodermal lineages
Human induced pluripotent stem cell (hiPSC) utility is limited by variations in the ability of these cells to undergo lineage-specific differentiation. We have undertaken a transcriptional comparison of human embryonic stem cell (hESC) lines and hiPSC lines and have shown that hiPSCs are inferior in their ability to undergo neuroectodermal differentiation. Among the differentially expressed can...
متن کاملRare genetic variants support mitochondrial dysfunction in Lewy body disorders.
Parkinson disease (PD) and other Lewy body disorders are common neurodegenerative conditions manifesting with progressive motor and nonmotor symptoms. Although their pathogenesis remains to be fully elucidated, a number of genetic findings have helped better understand the molecular mechanisms involved. Mutations in genes causing PD that are inherited in a Mendelian fashion as well as genetic v...
متن کاملAminochrome Induces Irreversible Mitochondrial Dysfunction by Inducing Autophagy Dysfunction in Parkinson's Disease
In Parkinson’s disease, mitochondrial complex I activity is diminished, and mitochondrial deoxyribonucleic acid (DNA) mutations accumulate (Zhang, 2013). The first evidence that mitochondrial dysfunction was involved in the pathogenesis of Parkinson’s disease came from parkinsonism induced by the accidental exposure of drug users to 1-methyl-4-phenyl-1,2,3,4tetrahydropyridine (MPTP), an inhibit...
متن کاملIchthyotoxic Cochlodinium polykrikoides Induces Mitochondrial Mediated Oxidative Stress and Apoptosis in Rat Liver Hepatocytes
In this research, we investigated the cytotoxic mechanisms of Cochlodinium polykrikoidescell lysate on isolated rat liver hepatocytes.This micro algae is responsible for a severe and widespread harmful algal bloom in the Persian Gulf and Gulf of Oman (2008-2009). Isolated hepatocytes were obtained by collagenase perfusion of Sprague-Dawley rat liver.According to our results, incubation of algal...
متن کامل